RETRACTED: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis

A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis

Scott Valastyan,1,2 Ferenc Reinhardt,1 Nathan Benaich,1,3 Diana Calogrias,4 Attila M. Szász,4 Zhigang C. Wang,5,6 Jane E. Brock,4 Andrea L. Richardson,4 and Robert A. Weinberg1,2,7,* 1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA 2Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 3Department of Biology, Williams College, Williamstown,...

Retraction Notice to: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis

MicroRNAs are well suited to regulate tumor metastasis because of their capacity to coordinately repress numerous target genes, thereby potentially enabling their intervention at multiple steps of the invasion-metastasis cascade. We identify a microRNA exemplifying these attributes, miR-31, whose expression correlates inversely with metastasis in human breast cancer patients. Overexpression of ...

synthetic canonical mir-31 , a pleiotropically acting anti-metastasis mir-based therapeutic in invasive breast cancer

Inhibition of breast cancer metastasis by co-transfection of miR-31/193b-mimics

Objective(s): Various studies have been conducted to reduce the metastatic behavior of cancerous cells. In this regard, ectopic expression of anti-metastatic microRNAs by miR-mimic and miR-restoration-based therapies could bring new insights to the field. In the present study, the consequences of co-transfecting breast cancer cell lines with miR-193b and miR-31 were investigated via invasion an...

MicroRNA-320a inhibits breast cancer metastasis by targeting metadherin

Dysregulated microRNAs play important pathological roles in carcinogenesis that are yet to be fully elucidated. This study was performed to investigate the biological functions of microRNA-320a (miR-320a) in breast cancer and the underlying mechanisms. Function analyses for cell proliferation, cell cycle, and cell invasion/migration, were conducted after miR-320a silencing and overexpression. T...